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PKR-mediated signaling

Summary
Species
Drosophila melanogaster
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Host RNA activators of PKREIF2AK2 dimer:Host RNA activatorsQ9NIV1PPiISG15:UBCH8:ISG15 E3 ligaseAMPHomologues of UBE2L6ATPISG15-EIF2AK2 dimerISG15 E3 ligasesp-PRKRA dimerp-PRKRA:EIF2AK2 dimerILF3ILF3:EIF2AK2 dimerEIF2AK2 dimer:heparinheparinEIF2AK2:NCK1NCK1Homologues of NPM1NPM1:EIF2AK2Homologues of p-TARBP2p-TARBP2:EIF2AK2Dus2DUS2:EIF2AK2STAT1,STAT3:EIF2AK2STAT3P58IPKDNAJC3:EIF2AK2EIF2AK2:p-SPHK1Q9VYY8PKR inhibitorsEIF2AK2:PKR inhibitorsP24785DHX9ADPP23572CDK1O62602licp-EIF2AK2 dimerp-EIF2AK2 dimerATPp-S392-TP53 tetramerTP53 TetramerADPQ86BI3ILF2:ILF3Q9VG73EIF2AK2:CHUK:IKBKB:IKBKGCHUK:IKBKB:IKBKGPTPN2Q9W0G1Sk1Q9VYY8Activated PPP2R5A-specific PP2APPP2R5A-specific PP2A
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying 1 entry
UniProt ID Protein Name Gene Symbol Pathway Viewer
Q9NIV1 Eukaryotic translation initiation factor 2-alpha kinase
  • EIF2AK3
  • PEK
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025