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MIRAGE
Prolactin receptor signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PRLR:JAK2PRLR:JAK2 dimerPRLR ligands:PRLR:JAK2 dimerPRLR ligands:Activated PRLR:JAK2 dimerATPPRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5ADPPRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5PRLR ligands:p-S349-PRLR:JAK2 dimerPRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complexBTRC:CUL1:RBX1:SKP1Activated cytokine-like hormone receptorsActivated cytokine-like hormone receptors, p-Y1007-JAK2JAK2PRLRProlactin receptor ligandsPRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 betaSH2B1-2PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimerPRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimerSTAT5SHP2PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2PRLR ligands:p-S349- PRLR:JAK2 dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025