Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
HSP90Ligand-responsive EGFR mutants:HSP90:CDC37Ligand-responsive EGFR mutantsCDC37EGF:Ligand-responsive EGFR mutants:HSP90:CDC37EGFEGF:Ligand-responsive EGFR mutants dimerLigand-responsive EGFR mutants dimerActive dimers of ligand-responsive EGFR mutantsADPLigand-responsive p-6Y-EGFR mutant dimersATPGRB2:SOS1:Phospho-EGFRmutKD:HSP90:CDC37GRB2-1:SOS1GTPp21 RAS:GTPGDPp21 RAS:GDPLigand-responsive p-6Y-EGFR mutants:SHC1SHCLigand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1GRB2:SOS1:Phospho-SHC1:Phospho-EGFRmutKD:HSP90:CDC37GRB2:GAB1Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1PIK3CA:PIK3R1Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3KPIP2PIP3PLC1Phospho-EGFRmutKD:PLCgamma1Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1p-PLCG1Ligand-responsive p-6Y-EGFR mutants:CBLCBLLigand-responsive p-6Y-EGFR mutants:p-Y371-CBLUbBenzoquinoid ansamycinsHSP90:Benzoquinoid ansamycinsReversible EGFR TKIsResistant ligand-responsive EGFR mutantsSensitive ligand-responsive EGFR mutants:Non-covalent EGFR TKIsIrreversible EGFR TKIsResistant ligand-responsive EGFR mutants:Covalent EGFR TKIs
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025