SHC1 events in ERBB2 signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-ERBB2 heterodimersSHC1:Phosphorylated ERBB2 heterodimersSHCATPp-Y349,350-SHC1:Phosphorylated ERBB2 heterodimersADPGRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimersGRB2-1:SOS1GTPp21 RAS:GTPGDPp21 RAS:GDPp-3Y-SHC1-1,p-3Y-SHC1-2p-S139,3Y-SHC1-1,p-S29,3Y-SHC1-2p-S139,3Y-SHC1-1,p-S29,3Y-SHC1-2:PTPN12PTPN12
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 16 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14511 Pro-neuregulin-2, membrane-bound isoform
  • NRG2
  • NTAK
view
O14944 Proepiregulin
  • EREG
view
P00533 Epidermal growth factor receptor
  • EGFR
  • ERBB
  • ERBB1
  • HER1
view
P01111 GTPase NRas
  • HRAS1
  • NRAS
view
P01112 GTPase HRas
  • HRAS
  • HRAS1
view
P01133 Pro-epidermal growth factor
  • EGF
view
P04626 Receptor tyrosine-protein kinase erbB-2
  • ERBB2
  • HER2
  • MLN19
  • NEU
  • NGL
view
P17252 Protein kinase C alpha type
  • PKCA
  • PRKACA
  • PRKCA
view
P29353 SHC-transforming protein 1
  • SHC
  • SHC1
  • SHCA
view
P35070 Probetacellulin
  • BTC
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025