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MIRAGE
MyD88:MAL(TIRAP) cascade initiated on plasma membrane

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
TRAF6MEKK1:activated TRAF6MEKK1TIRAPMAL:PI(4,5)P2PIP2Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimerMAL:PI(4,5)P2:activated TLR2/4MAL:PI(4,5)P2:BTK:activated TLR2/4BTKactivated TLR2/4:p-4Y-MAL:PI(4,5)P2:BTKATPADPMYD88MyD88:MAL:BTK:activated TLR2/4oligo-MyD88:TIRAP:BTK:activated TLRIRAK4IRAK4:oligo-MyD88:TIRAP:activated TLRp-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptorIRAK1, IRAK2IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:Mal:activated TLRIRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLRp-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLRIRAK1:p-S,2T-IRAK4 :oligo-MyD88:MAL:activated TLRp-IRAK1:p-IRAK4:oligo-MyD88:MAL:activated TLRpp-IRAK1:p-IRAK4:oligo-MyD88:MAL:activated TLRp-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLRTRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLRTRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:MAL:activated TLRTRAF6:hp-IRAK1TRAF6:p-IRAK2
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025