Signaling by PDGF

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PDGF precursor dimers (AA, BB, A/B, CC, DD)PDGF precursor dimers (AA, BB, A/B, CC, DD)proPDGF-AA dimeractive PDGF-AA dimerN-ter PDGF-A fragmentproPDGF-BB dimeractive PDGF-BB dimerCleaved PDGF-B peptidesproPDGF-AB dimerPDGF A/B heterodimerPDGFA_HUMANNovel PDGF precursor dimers (CC, DD)Novel PDGF precursor dimers (CC, DD)Cleaved novel PDGF fragmentsActive PDGF dimers (CC, DD)Extracellular matrix ligandsPDGF A and B chains:ECM complexPDGF A and B chains with retention motifPDGFRA, PDGFRBPDGF:PDGF receptor dimerActive PDGF dimers (AA, AB, BB)PDGF beta receptor:PDGF chain B homodimerADPATPPhospho PDGF beta receptor: PDGF chain B homodimerPhospho PDGF alpha receptor:PDGF dimersPDGF alpha receptor: PDGF dimersPhospho PDGF alpha-beta dimer:PDGF AB or BB dimersPDGF alpha/beta:PDGF AB and BB dimersH2OPip-PDGFRB homo and heterodimersp-PDGFRB homo and heterodimers dephosphorylated at Y1021PDGFRAPDGFRA:olaratumabIMC-3G3type I PDGFR-binding tyrosine kinase inhibitorsPDGFR:type I PDGFR-binding TKIstype II PDGFR-binding tyrosine kinase inhibitorsPDGFR:type II PDGFR-binding TKIs
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying 1 entry
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_001410 P20849 Collagen alpha-1(IX) chain view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025