NOTCH1 Intracellular Domain Regulates Transcription

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PCAFNOTCH1 Coactivator ComplexNICD1:RBPJ:SNW1MAMLKAT3Ap300HES1 geneHES1NOTCH1 Coactivator Complex:MYC GeneMYC geneMYCHES5 geneNOTCH1 Coactivator Complex:HES5 GeneNOTCH1 Coactivator Complex:HEY GenesHEY GenesCDK8:CCNCNOTCH1 Coactivator Complex:CDK8:CCNCFBXW7:SKP1:CUL1:RBX1p-NICD1:FBXW7:SKP1:CUL1:RBX1p-NICD1UbUb-p-NICD1HIF1ANICD1:HIF1ANICD1NICD1:NBEANBEACSL NCOR corepressor complexNCOR:HDAC:TBL1NOTCH1 Coactivator Complex:HES1 GeneTLEHES1:TLEHES5HEYATPRBPJ:SNW1ADPNBEA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 11 - 20 of 30 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
Q04725 Transducin-like enhancer protein 2
  • TLE2
view
Q04727 Transducin-like enhancer protein 4
  • GRG4
  • KIAA1261
  • TLE4
view
Q06330 Recombining binding protein suppressor of hairless
  • IGKJRB
  • IGKJRB1
  • RBPJ
  • RBPJK
  • RBPSUH
view
Q09472 Histone acetyltransferase p300
  • EP300
  • P300
view
Q13495 Mastermind-like domain-containing protein 1
  • CG1
  • CXorf6
  • MAMLD1
view
Q13547 Histone deacetylase 1
  • HDAC1
  • RPD3L1
view
Q13573 SNW domain-containing protein 1
  • SKIIP
  • SKIP
  • SNW1
view
Q14469 Transcription factor HES-1
  • BHLHB39
  • HES1
  • HL
  • HRY
view
Q16665 Hypoxia-inducible factor 1-alpha
  • BHLHE78
  • HIF1A
  • MOP1
  • PASD8
view
Q8IZL2 Mastermind-like protein 2
  • KIAA1819
  • MAML2
view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025