NOTCH1 Intracellular Domain Regulates Transcription

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
NICD1NCOR:HDAC:TBL1CSL NCOR corepressor complexNICD1:RBPJ:SNW1p300NOTCH1 Coactivator ComplexMAMLPCAFKAT3AHES1 geneNOTCH1 Coactivator Complex:HES1 GeneHES1TLEHES1:TLEMYC geneNOTCH1 Coactivator Complex:MYC GeneMYCHES5 geneNOTCH1 Coactivator Complex:HES5 GeneHES5HEY GenesNOTCH1 Coactivator Complex:HEY GenesHEYCDK8:CCNCNOTCH1 Coactivator Complex:CDK8:CCNCATPRBPJ:SNW1p-NICD1ADPp-NICD1:FBXW7:SKP1:CUL1:RBX1FBXW7:SKP1:CUL1:RBX1UbUb-p-NICD1HIF1ANICD1:HIF1ANBEANBEANICD1:NBEA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 21 - 30 of 30 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
Q8NFP9 Neurobeachin
  • BCL8B
  • KIAA1544
  • LYST2
  • NBEA
view
Q8WUI4 Histone deacetylase 7
  • HDAC7
  • HDAC7A
view
Q92585 Mastermind-like protein 1
  • KIAA0200
  • MAML1
view
Q92769 Histone deacetylase 2
  • HDAC2
view
Q92793 CREB-binding protein
  • CBP
  • CREBBP
view
Q92830 Histone acetyltransferase KAT2A
  • GCN5
  • GCN5L2
  • KAT2A
view
Q96JK9 Mastermind-like protein 3
  • KIAA1816
  • MAML3
view
Q9UBN7 Histone deacetylase 6
  • HDAC6
  • KIAA0901
view
Q9UKV0 Histone deacetylase 9
  • HDAC7
  • HDAC7B
  • HDAC9
  • HDRP
  • KIAA0744
  • MITR
view
Q9Y618 Nuclear receptor corepressor 2
  • CTG26
  • NCOR2
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025