Insulin processing

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Proinsulin6xHC-INS(25-110)PDIA1P4HBO2H2O26xHC-INS(25-110)Ca2+6xProinsulin:2xZn2+:1xCa2+Zn2+6xProinsulin:2xZn2+:1xCa2+6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+H2O6x2xHC-INS(25-54):4xHC-INS(57-110):2xZn2+:1xCa2+6xInsulin:2xZn2+:Ca2+INS_HUMANL-ArgC PeptideL-Lys6xInsulin:2xZn2+:Ca2+ (post actin network)6xInsulin:2xZn2+:Ca2+ (docked granule)EXOC8Exocyst ComplexEXOC7EXOC3EXOC1EXOC4EXOC6EXOC2EXOC5Zn2+Zn2+
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 13 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
P07237 Protein disulfide-isomerase
  • ERBA2L
  • P4HB
  • PDI
  • PDIA1
  • PO4DB
view
P16519 Neuroendocrine convertase 2
  • NEC2
  • PCSK2
view
P16870 Carboxypeptidase E
  • CPE
view
P29120 Neuroendocrine convertase 1
  • NEC1
  • PCSK1
view
P33176 Kinesin-1 heavy chain
  • KIF5B
  • KNS
  • KNS1
view
Q16623 Syntaxin-1A
  • STX1
  • STX1A
view
Q86YB8 ERO1-like protein beta
  • ERO1B
  • ERO1LB
view
Q8NFW9 Rab effector MyRIP
  • MYRIP
  • SLAC2C
view
Q8TAD4 Proton-coupled zinc antiporter SLC30A5
  • SLC30A5
  • ZNT5
  • ZNTL1
  • ZTL1
view
Q96A65 Exocyst complex component 4
  • EXOC4
  • KIAA1699
  • SEC8
  • SEC8L1
view
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025