Smooth Muscle Contraction

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CALM1CALM1:4xCa2+Ca2+H+GDNNOH2OGTNGuanylate cyclase, solubleGuanylate cyclase:NONOsGC stimulatorsNO:sGC:sGC stimulatorsNO:sGC:cinaciguatcinaciguatGTPPPicGMPPDE5A dimerPDE5A dimer:PDE5A inhibitorsPDE5A inhibitorsT-type VDCCT-type VDCC:T-type VDCC blockersT-type VDCC blockersMYLKMYLK:Ca2+:CALM1Smooth Muscle Myosin Light ChainADPATPPhosphorylated Smooth Muscle Myosin Light ChainInactive Myosin Actin Contractile ComplexCalcium Bound Myosin Actin ComplexADP:Calcium Bound Myosin Actin ComplexATP:Calcium Bound Myosin Actin Complexp-S CALD1-Calcium Bound Myosin Actin ComplexPiDYSFCAV3:TRIM72:DYSFTRIM72CAV3ANXA6CAV3:TRIM72:DYSF:ANXA6:ANXA1:ANXA2ANXA2ANXA1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 28 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O43497 Voltage-dependent T-type calcium channel subunit alpha-1G
  • CACNA1G
  • KIAA1123
view
O60504 Vinexin
  • SCAM1
  • SORBS3
view
O75923 Dysferlin
  • DYSF
  • FER1L1
view
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase
  • PDE5
  • PDE5A
view
O95180 Voltage-dependent T-type calcium channel subunit alpha-1H
  • CACNA1H
view
P04083 Annexin A1
  • ANX1
  • ANXA1
  • LPC1
view
P05091 Aldehyde dehydrogenase, mitochondrial
  • ALDH2
  • ALDM
view
P07355 Annexin A2
  • ANX2
  • ANX2L4
  • ANXA2
  • CAL1H
  • LPC2D
view
P08133 Annexin A6
  • ANX6
  • ANXA6
view
P14649 Myosin light chain 6B
  • MLC1SA
  • MYL6B
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025