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MIRAGE
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ZFP36TTP:mRNA ComplexTNPO1mRNA Transcript Targeted by TristetraprolineExosome ComplexTTP:mRNA Degradation ComplexDCP1ADCP2XRN1ATPADPPhosphorylated TTP:mRNA ComplexPhosphorylated TTP:mRNA:14-3-3 ComplexYWHAB
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 7 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
Q13868 Exosome complex component RRP4
  • EXOSC2
  • RRP4
 view
Q15024 Exosome complex component RRP42
  • EXOSC7
  • KIAA0116
  • RRP42
 view
Q8IZH2 5'-3' exoribonuclease 1
  • SEP1
  • XRN1
 view
Q92973 Transportin-1
  • KPNB2
  • MIP1
  • TNPO1
  • TRN
 view
Q96B26 Exosome complex component RRP43
  • EXOSC8
  • OIP2
  • RRP43
 view
Q9NPI6 mRNA-decapping enzyme 1A
  • DCP1A
  • SMIF
 view
Q9NQT4 Exosome complex component RRP46
  • CML28
  • EXOSC5
  • RRP46
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025