Thrombin signalling through proteinase activated receptors (PARs)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PAR3, 4PAR N-teminal fragmentsThrombin-activated PARspro-F2RF2R(27-41)F2R(42-425)vorapaxarpro-F2R:vorapaxarThrombin-activated PARs:Gq (inactive)Heterotrimeric G-protein Gq/11 (inactive)GTPGDPThrombin-activated PAR:Gq (active)G-protein beta-gamma complexG-protein alpha (q/11): GTPThrombin activated PAR:G12/13 (inactive)G-protein G12/G13 (inactive)Thrombin activated PAR:G12/13 (active)G-protein alpha (12/13):GTPARRB1F2R:ARRB1ARRB2F2R:ARRB2SRC1F2R:ARRB1:MAPKs:SRC-1MAPKsF2R:ARRB2:MAPKs:SRC-1F2R:ARRB1:MAPKs:active SRC-1F2R:ARRB1:active MAPKs:active SRC-1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025