Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MSH2MSH2:MSH6:ADPADPMSH6DNA containing mismatch or 1-2 base IDLMSH2:MSH6:ADP:DNA containing 1-2 base mismatchMSH2:MSH6:ATP:DNA containing 1-2 base mismatchATPPMS2MLH1:PMS2MLH1MutLalpha:MutSalpha:ATP:PCNA:DNA with 1-2 base mismatchPCNA homotrimerMutLalpha:MutSalpha:ATP:PCNA:DNA with 1-2 base mismatch and single strand incisionEXO1EXO1:MutLalpha:MutSalpha:ATP:PCNA:DNA with 1-2 base mismatch and single strand incisionRPA heterotrimerRPA:DNA containing single strand gapdCTPDNA containing single strand nick (5' phosphate, 3' hydroxyl)dGTPTTPdATPPPiAMPRepaired double-stranded DNA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025