Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
TTPRPA heterotrimerdGTPRPA:DNA containing single strand gapDNA containing single strand nick (5' phosphate, 3' hydroxyl)dCTPdATPAMPPPiATPRepaired double-stranded DNAMSH2MutSbeta:ADPMSH3ADPDNA containing IDL of 2 or more basesMutSbeta:ADP:DNA containing IDL of 2 bases or moreMutSbeta:ATP:DNA containing IDL of 2 bases or morePCNA homotrimerMutSbeta:MutSalpha:ATP:PCNA:DNA containing 1-2 base IDLMLH1:PMS2MutLalpha:MutSbeta:ATP:PCNA:DNA containing 1-2 base IDL and single strand incisionEXO1:MutLalpha:MutSbeta:ATP:PCNA:DNA containing 1-2 base IDL and single strand incisionEXO1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025