RHO GTPases activate PAKs

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MYLKMYLK:Ca2+:CALM1CALM1:4xCa2+CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3Active RAC1/CDC42ADPATPp-S,T-PAK1,2,3H2OPip-T19,S20-MRLC-smooth muscle/non-muscle myosin IISmooth muscle/non-muscle myosin IIPAK1 dimerPAK1RAC1:GTP,CDC42:GTP:PAK1CDC42:GTP,RAC1:GTP:PAK2PAK2 dimerPAK2PAK3 dimerPAK3CDC42:GTP,RAC1:GTP:PAK3LIMK1p-T508-LIMK1p-T19-MRLC-Smooth muscle/non-muscle myosin IIMyosin phosphatasep-T696-PPP1R12A-Myosin phosphatasep-S1208,S1759-MYLK(1-1914)NF2PAK1:NF2CTTNp-S113-CTTNp-S144,T423-PAK1p-S144,T423-PAK1:FLNAFLNAp-S2152-FLNA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025