RHO GTPases activate PAKs

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-T19,S20-MRLC-smooth muscle/non-muscle myosin IISmooth muscle/non-muscle myosin IIH2OPiActive RAC1/CDC42PAK2PAK2 dimerCDC42:GTP,RAC1:GTP:PAK2LIMK1p-T508-LIMK1ATPADPp-T19-MRLC-Smooth muscle/non-muscle myosin IIMyosin phosphatasep-T696-PPP1R12A-Myosin phosphatasep-S1208,S1759-MYLK(1-1914)MYLKp-S113-CTTNCTTNp-S144,T423-PAK1:FLNAp-S2152-FLNAp-S144,T423-PAK1MYLK:Ca2+:CALM1CALM1:4xCa2+CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3p-S,T-PAK1,2,3PAK1 dimerPAK1RAC1:GTP,CDC42:GTP:PAK1PAK3 dimerCDC42:GTP,RAC1:GTP:PAK3PAK3PAK1:NF2NF2FLNA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025