Signaling by FGFR3 in disease

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Activated FGFR3 point, translocation and fusion mutants:FRS2Activated FGFR3 point, translocation and fusion mutants:p-FRS2ATPADPGTPp21 RAS:GTPGDPp21 RAS:GDPActivated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3KPIK3CAPLC1Activated FGFR3 point and translocation mutants: PLCG1Activated FGFR3 point and translocation mutantsPIP3Activated FGFR3 point and translocation mutants:p-4Y-PLCG1p-PLCG1FGFR3 mutant dimersFGFR3 mutant dimers:TKIsTyrosine kinase inhibitors of FGFR3 mutantsFRS2Activated FGFR3 point, translocation and fusion mutantsGRB2-1:SOS1FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1GRB2:GAB1:PIK3R1PIP2
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025