RHO GTPases Activate WASPs and WAVEs

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PIP3WRC:IRSp53/58:RAC1:GTP:PIP3RAC1:GTPBAIAP2WRCp-Y-WRC:IRSp53/58:RAC1:GTP:PIP3p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ATPADPPIP2CDC42:GTP:WASP/N-WASPCDC42:GTPWASP/N-WASPCDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsSH3 domain proteinsWIP family proteinsCDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsARP2/3 complex (ATP bound)WAVE2, WASP, N-WASP:ARP2/3 complex:G-actinWAVE2, WASP, N-WASPG-actinMother filament:branching complexF-actinMother filament:ARP2/3:actin:ADPMother filament:branching complex:daughter filament
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025