TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CD40LG trimerCD40:CD40L trimerCD40 trimerLTBR ligandsLTBR:lymphotoxin,TNFSF14 trimerLTBRcIAP1,2:TRAF2:TRAF3:NIK3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK3xLTBR:lymphotoxin,TNFSF14 trimerCD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIKsBAFF trimer3xBAFFR:BAFF trimerBAFFRRANKRANK:RANKL,sRANKL trimerRANKL,sRANKL trimer3xRANK:RANKL,sRANKL trimer3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK3xFN14:sTWEAK,TWEAK homotrimer3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK3xBAFFR:BAFF trimer:TRAF3:NIKsTWEAK,TWEAK homotrimersFN14
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 11 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14788 Tumor necrosis factor ligand superfamily member 11
  • OPGL
  • RANKL
  • TNFSF11
  • TRANCE
view
O43508 Tumor necrosis factor ligand superfamily member 12
  • APO3L
  • DR3LG
  • TNFSF12
view
O43557 Tumor necrosis factor ligand superfamily member 14
  • HVEML
  • LIGHT
  • TNFSF14
view
P01374 Lymphotoxin-alpha
  • LTA
  • TNFB
  • TNFSF1
view
P29965 CD40 ligand
  • CD40L
  • CD40LG
  • TNFSF5
  • TRAP
view
P36941 Tumor necrosis factor receptor superfamily member 3
  • D12S370
  • LTBR
  • TNFCR
  • TNFR3
  • TNFRSF3
view
Q06643 Lymphotoxin-beta
  • LTB
  • TNFC
  • TNFSF3
view
Q13490 Baculoviral IAP repeat-containing protein 2
  • API1
  • BIRC2
  • MIHB
  • RNF48
view
Q96RJ3 Tumor necrosis factor receptor superfamily member 13C
  • BAFFR
  • BR3
  • TNFRSF13C
view
Q9Y275 Tumor necrosis factor ligand superfamily member 13B
  • BAFF
  • BLYS
  • TALL1
  • TNFSF13B
  • TNFSF20
  • ZTNF4
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025