Nonhomologous End-Joining (NHEJ)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexUIMC1BRERIF1p-5S-BRCA1:p-2T-BARD1BRCC3NBA1PTIPDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1p-S406-ABRA1p-S1981,Ac-K3016-ATMp-MRNp-T4827,SUMO1-HERC2XRCC5:XRCC6p-5T-MDC1KAT5p-S25,S1778-TP53BP1RNF168K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-NucleosomeXRCC5:XRCC6:DNA DSBsPIAS4UBC13:MMS2p-S102-WHSC1RNF8:Zn2+DNA-PK holoenzymePRKDCASCIDDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1Cp-S645-DCLRE1CADPATPp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Ligatable DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB endsXRCC4:LIG4POLL,POLMNHEJ1PPidNTPp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB endsp-DNA-PKcsp-S516,S645-DCLRE1Cds DNA, mutated dsDNA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 35 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O60814 Histone H2B type 1-K
  • H2BC12
  • H2BFT
  • HIRIP1
  • HIST1H2BK
view
O60934 Nibrin
  • NBN
  • NBS
  • NBS1
  • P95
view
O95714 E3 ubiquitin-protein ligase HERC2
  • HERC2
view
O96028 Histone-lysine N-methyltransferase NSD2
  • KIAA1090
  • MMSET
  • NSD2
  • TRX5
  • WHSC1
view
P06899 Histone H2B type 1-J
  • H2BC11
  • H2BFR
  • HIST1H2BJ
view
P12956 X-ray repair cross-complementing protein 6
  • G22P1
  • XRCC6
view
P13010 X-ray repair cross-complementing protein 5
  • G22P2
  • XRCC5
view
P16104 Histone H2AX
  • H2AFX
  • H2AX
view
P23527 Histone H2B type 1-O
  • H2BC17
  • H2BFH
  • H2BFN
  • HIST1H2BO
view
P33778 Histone H2B type 1-B
  • H2BC3
  • H2BFF
  • HIST1H2BB
view
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Last updated: February 17, 2025