Nonhomologous End-Joining (NHEJ)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PTIPBREDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexp-S406-ABRA1UIMC1NBA1DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1RIF1BRCC3p-5S-BRCA1:p-2T-BARD1p-S1981,Ac-K3016-ATMKAT5XRCC5:XRCC6UBC13:MMS2XRCC5:XRCC6:DNA DSBsRNF168p-S102-WHSC1p-T4827,SUMO1-HERC2p-5T-MDC1p-S25,S1778-TP53BP1PIAS4p-MRNK63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-NucleosomeRNF8:Zn2+DNA-PK holoenzymePRKDCDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1CASCIDATPADPp-S645-DCLRE1Cp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Ligatable DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB endsNHEJ1POLL,POLMXRCC4:LIG4dNTPp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB endsPPip-DNA-PKcsp-S516,S645-DCLRE1Cds DNA, mutated dsDNA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 11 - 20 of 35 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
P38398 Breast cancer type 1 susceptibility protein
  • BRCA1
  • RNF53
view
P49959 Double-strand break repair protein MRE11
  • HNGS1
  • MRE11
  • MRE11A
view
P57053 Histone H2B type F-S
  • H2BC12L
  • H2BFS
  • H2BS1
view
P58876 Histone H2B type 1-D
  • H2BC5
  • H2BFB
  • HIRIP2
  • HIST1H2BD
view
P62805 Histone H4
  • H4-16
  • H4/A
  • H4/B
  • H4/C
  • H4/D
  • H4/E
  • H4/G
  • H4/H
  • H4/I
  • H4/J
  • H4/K
  • H4/M
  • H4/N
  • H4/O
  • H4C1
  • H4C11
  • H4C12
  • H4C13
  • H4C14
  • H4C15
  • H4C16
  • H4C2
  • H4C3
  • H4C4
  • H4C5
  • H4C6
  • H4C8
  • H4C9
  • H4F2
  • H4FA
  • H4FB
  • H4FC
  • H4FD
  • H4FE
  • H4FG
  • H4FH
  • H4FI
  • H4FJ
  • H4FK
  • H4FM
  • H4FN
  • H4FO
  • HIST1H4A
  • HIST1H4B
  • HIST1H4C
  • HIST1H4D
  • HIST1H4E
  • HIST1H4F
  • HIST1H4H
  • HIST1H4I
  • HIST1H4J
  • HIST1H4K
  • HIST1H4L
  • HIST2H4
  • HIST2H4A
  • HIST2H4B
  • HIST4H4
view
P62807 Histone H2B type 1-C/E/F/G/I
  • H2BC10
  • H2BC4
  • H2BC6
  • H2BC7
  • H2BC8
  • H2BFA
  • H2BFG
  • H2BFH
  • H2BFK
  • H2BFL
  • HIST1H2BC
  • HIST1H2BE
  • HIST1H2BF
  • HIST1H2BG
  • HIST1H2BI
view
P78527 DNA-dependent protein kinase catalytic subunit
  • HYRC
  • HYRC1
  • PRKDC
view
Q12888 TP53-binding protein 1
  • TP53BP1
view
Q13315 Serine-protein kinase ATM
  • ATM
view
Q14676 Mediator of DNA damage checkpoint protein 1
  • KIAA0170
  • MDC1
  • NFBD1
view
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