Fanconi Anemia Pathway

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
FAAP24FANCM:FAAP24FANCMICL-DNAFANCM:FAAP24:APITD1:STRA13:ICL-DNAMHF octamerFANCIID2 complexFANCD2ATR:ATRIPFANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIPRPA heterotrimerID2 Complex:UBE2T:FA Core Complex:ICL-DNAUbMonoUb:K91,K182-UBE2Tp-ID2 Complex:UBE2T:p-FA Core Complex:ICL-DNAMonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNAp-FA Core Complex:ICL-DNAp-ID2 complexMonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleasesERCC1:ERCC4DCLRE1A,DCLRE1BSLX1A:SLX4:MUS81:EME1,(MUS81:EME2)FAN1POLNMonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLNMonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNAFANCBFA Core Complex:ICL-DNAFANCEFANCGFANCAFANCLFANCFFAAP20FANCCFAAP100UBE2TATPp-RPA heterotrimerADPDistorted dsDNAdNTPPPip-FA Core ComplexMonoubiquitinated ID2 complexDNA double-strand break ends
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025