TP53 Regulates Transcription of DNA Repair Genes

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MSH2 GeneAP-1:p-S15,S20-TP53 Tetramer:MSH2 Genep-S15,S20-TP53 TetramerAP-1MSH2p-S15,S20-TP53 Tetramer:PMS2 GenePMS2 GenePMS2MLH1 Genep-S15,S20-TP53 Tetramer:MLH1 GeneMLH1p-S15,S20-TP53 Tetramer:FANCC GeneFANCC GeneFANCCp-S15,S20-TP53 Tetramer:DDB2 GeneDDB2 GeneDDB2p-S15,S20-TP53 Tetramer:CCNK GeneCCNK GeneCCNKCCNK:CDK12CRK7CHEDCCNK:CDK13Elongation Complex at DNA Repair GenesCCNK:CDK12:Elongation Complex at DNA Repair GenesATPADPCCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genesDNA repair genes regulated by CDK12BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025