Regulation of TP53 Degradation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
SGK1ADPATPp-S422-SGK1p-T256,S422-SGK1MDM2p-MDM2p-S15,S20-TP53 Tetramerp-S15,S20-TP53 Tetramer:MDM2 GeneMDM2 geneMDM2p-MDM2p-S166,S188-MDM2 dimerPolyUb,p-S166,S188-MDM2 homodimerUbH2Op-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4)USP7DAXXDAXX:(PolyUb,p-S166,S188-MDM2):USP7PolyUb-TP53 TetramerTP53 TetramerPolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4USP2:PolyUb-MDM2:PolyUb-MDM4USP2p14ARFp14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4ATPp-S166,S188,T218-MDM2ADPCCNG1 GeneCCNGp-T218,S166,S188-MDM2, p-S166,S188-MDM2PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2)PP2A-PPP2R5CPip-5S,T-MDM2p-S166,S188-MDM2:MDM4p-S166,S188-MDM2:p-S403-MDM4p-S166,S188-MDM2:p-S346,S367,S403-MDM4p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4PolyUb-TP53 TetramerPolyUb,p-S166,S188-MDM2:(PolyUb,p-S166,S188-MDM2, PolyUb,p-S342,S367,S403-MDM4)PolyUbTP53 Tetramer:CCNG1 GenePolyUb,p-S15,S20-TP53 Tetramerp-S166,S188-MDM2,MDM4
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025