G2/M DNA damage checkpoint

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Chk1phospho-Chk1ATPADPDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complexDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2Chk2Cds1p-T68-CHEK2 dimerp-S,3T-CHEK2p-S15-TP53 TetramerTP53 Tetramerp-S15,S20-TP53 Tetramer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 43 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14757 Serine/threonine-protein kinase Chk1
  • CHEK1
  • CHK1
view
O60814 Histone H2B type 1-K
  • H2BC12
  • H2BFT
  • HIRIP1
  • HIST1H2BK
view
O60934 Nibrin
  • NBN
  • NBS
  • NBS1
  • P95
view
O75943 Cell cycle checkpoint protein RAD17
  • R24L
  • RAD17
view
O95714 E3 ubiquitin-protein ligase HERC2
  • HERC2
view
O96017 Serine/threonine-protein kinase Chk2
  • CDS1
  • CHEK2
  • CHK2
  • RAD53
view
O96028 Histone-lysine N-methyltransferase NSD2
  • KIAA1090
  • MMSET
  • NSD2
  • TRX5
  • WHSC1
view
P04637 Cellular tumor antigen p53
  • P53
  • TP53
view
P06899 Histone H2B type 1-J
  • H2BC11
  • H2BFR
  • HIST1H2BJ
view
P15927 Replication protein A 32 kDa subunit
  • REPA2
  • RPA2
  • RPA32
  • RPA34
view
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.2.1

Last updated: April 7, 2025