Cargo recognition for clathrin-mediated endocytosis

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
AP-2 ComplexAP-2:cargoAP-2 cargoLDL:LDLR complexDAB2,LDLRAP1:LDLR:LDLDAB2,LDLRAP1DAB2LRP2:DAB2LRP2ubiquitinated cargoEPS15,EPN1,EPN2:ubiquitinated cargoEPS15,EPN1,EPN2UNQLNs:UIM proteinsUBQLN2,1ATPp-AVPR2:AVP(20-28)ADPAVPR2:AVP(20-28)ARRBARRB:ARRB-binding GPCRsARRB-binding GPCRsPI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1ARBBs:ARBB-binding GPCRs:clathrin-coated pitAGFG1AGFG1:VAMP7VAMP7SYT dimersSTON2,1:SYT dimersSTON2,1NEDD8(1-81)NEDD8-STONsNEDD8-STONs:TOR1 hexamer:COP9COP9TOR1 hexamerPICALMsPICALM:VAMP2,3,8VAMP2,3,8AP2:chlorpromazinechlorpromazine
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 79 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14526 F-BAR domain only protein 1
  • FCHO1
  • KIAA0290
view
O14656 Torsin-1A
  • DQ2
  • DYT1
  • TA
  • TOR1A
  • TORA
view
O14657 Torsin-1B
  • DQ1
  • TOR1B
view
O14944 Proepiregulin
  • EREG
view
O14964 Hepatocyte growth factor-regulated tyrosine kinase substrate
  • HGS
  • HRS
view
O43493 Trans-Golgi network integral membrane protein 2
  • TGN46
  • TGN51
  • TGOLN2
view
O60641 Clathrin coat assembly protein AP180
  • KIAA0656
  • SNAP91
view
O75886 Signal transducing adapter molecule 2
  • HBP
  • STAM2
view
O94973 AP-2 complex subunit alpha-2
  • ADTAB
  • AP2A2
  • CLAPA2
  • HIP9
  • HYPJ
  • KIAA0899
view
O95208 Epsin-2
  • EPN2
  • KIAA1065
view
Displaying all 2 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_002343 P11717 Cation-independent mannose-6-phosphate receptor view
GL_002467 Q9NY64 Solute carrier family 2, facilitated glucose transporter member 8 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025