Response of EIF2AK4 (GCN2) to amino acid deficiency

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ATF4 mRNAATF4DDIT3 mRNACHOPTRIB3 geneATF4:CEBPB,CEBPG,DDIT3:TRIB3 geneCEBPB,CEBPG,DDIT3TRIB3ATF4:CEBPB,CEBPG:ASNS geneASNS geneCEBPB,CEBPGASNSGCN2:GCN1:80S ribosome:mRNAtRNA:EIF2AK4:GCN1:80S Ribosome:mRNAtRNAADPtRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNAATPp-S52-EIF2S1:EIF2S2:EIF2S3MPATF4 dimer:p-T69,T71-ATF2 dimer:DDIT3 genep-T69,T71-ATF2DDIT3 geneATF4:ATF3 geneATF3 geneATF3CEBPB geneATF4:CEBPB geneLAPIMPACTIMPACT:GCN1:80S ribosome:mRNAGCN1:80S ribosome:mRNA
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025