Signaling by ERBB2 TMD/JMD mutants

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37HSP90Ligand-Activated EGFR,ERBB3,(ERBB4)ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4)CDC37LAP2p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)ADPATPSHCp-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1GRB2-1:SOS1p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1GTPp21 RAS:GTPGDPp21 RAS:GDPp-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFRp-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR:GRB2:SOS1p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFRp-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR:PLCG1PLC1p-PLCG1ERBB2 TMD/JMD mutants (TKI sensitive):ERBIN:HSP90:CDC37ERBB2 TMD/JMD mutants (TKI sensitive):TKI:ERBIN:HSP90:CDC37Anti-ERBB2 TKIsERBB2 TMD/JMD mutants (trastuzumab):ERBIN:HSP90:CDC37ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab:ERBIN:HSP90:CDC37D5v8pertuzumabERBB2 R678Q:pertuzumab:ERBIN:HSP90:CDC37ERBB2 R678Q:ERBIN:HSP90:CDC37
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025