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MIRAGE
Signaling by FLT3 ITD and TKD mutants

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
FLT3 extracellular domain, kinase domain and juxtamembrane domain mutantsFLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimersADPATPp-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimersp-6Y FLT3 mutant dimers:GRB2GRB2SOS1p-6Y FLT3 mutant dimers:GRB2:SOS1GTPp21 RAS:GTPGDPp21 RAS:GDPp-6Y FLT3 mutant dimers:GRB2:GAB2GAB2p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2SHP2p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2:PTPN11p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2:PIK3R1PIK3R1PIK3CAp-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PI3K
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 6 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P01111 GTPase NRas
  • HRAS1
  • NRAS
 view
P01112 GTPase HRas
  • HRAS
  • HRAS1
 view
P36888 Receptor-type tyrosine-protein kinase FLT3
  • CD135
  • FLK2
  • FLT3
  • STK1
 view
P62993 Growth factor receptor-bound protein 2
  • ASH
  • GRB2
 view
Q06124 Tyrosine-protein phosphatase non-receptor type 11
  • PTP2C
  • PTPN11
  • SHPTP2
 view
Q07889 Son of sevenless homolog 1
  • SOS1
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025