KEAP1-NFE2L2 pathway

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
UBXN7ub-UBXN7UbKEAP1:NEDD8-CUL3:RBX1KEAP1:NEDD8-CUL3:RBX1:NFE2L2NFE2L2ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1UBXN7:NPLOC4:UBF1:VCP hexamerNPLOC4:UBF1:VCP hexamerub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamerub-NFE2L2ATPp-S,T-NFE2L2ADPp-S40-NFE2L2p-NFE2L2p-NFE2L2p62SQSTM1 oligomerp-S349 SQSTM1 oligomerp-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1SESN1,2SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1NEDD8-CUL3:RBX1MAP1LC3B:SESN1,2:ub K420 p-S349 SQSTM1 oligomer:ub-KEAP1XSQSTM1 oliogmer:Xp62NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2NFE2L2 inducersMAP1LC3B
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025