Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
SMG1 ComplexSMG1:UPF1:EJC:Translated mRNPTranslated mRNA Complex with Premature Termination Codon Preceding Exon JunctionUPF1SMG1:Phosphorylated UPF1:EJC:Translated mRNPADPATPDCP1APhosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNPSMG7SMG6SMG5PP2A (Aalpha:B55alpha:Calpha)PNRC2mRNA Cleaved by SMG6P220Cap Binding Complex (CBC)PABP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025