Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
SMG1 ComplexSMG1:UPF1:EJC:Translated mRNPTranslated mRNA Complex with Premature Termination Codon Preceding Exon JunctionUPF1ATPADPSMG1:Phosphorylated UPF1:EJC:Translated mRNPSMG6Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNPSMG5PP2A (Aalpha:B55alpha:Calpha)PNRC2DCP1ASMG7mRNA Cleaved by SMG6Cap Binding Complex (CBC)P220PABP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025