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NFE2L2 regulating anti-oxidant/detoxification enzymes

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PRDX1 dimerH2OH2O2HOOS-C52-PRDX1 dimerGSR geneGSR gene:p-NFE2L2p-NFE2L22xGSR-2:2xFADPRDX1 genePRDX1 gene:p-NFE2L2SRXN1 gene:p-NFE2L2SRXN1 geneSRXN1HMOX1 geneHMOX1 gene:p-NFE2L2:MAFKMAFKHMOX1 dimerNQO1 geneNQO1 gene:p-AcK-NFE2L2:MAFKp-AcK-NFE2L2:CREBBP, EP300NQO1:FAD dimerGSTA1 geneGSTA1 gene:p-AcK-NFE2L2:MAFK:CREBBP, EP300GSTA1 dimerGSTA3 geneGSTA3 gene:p-NFE2L2GSTA3 dimerGCLC gene:p-AcK-NFE2L2:CREBBP, EP300GCLC geneGCLCGCLM geneGCLM gene:p-AcK-NFE2L2:CREBBP, EP300GCLMTXNRD1 gene:p-AcK-NFE2L2TXNRD1 geneTRNFE2L2 SOD3 gene complexSOD3 geneSOD3Thioredoxin geneTXN gene:p-AcK-NFE2L2:CREBBP,EP300:MAFKTXNSLC7A11 geneSLC7A11 gene:p-AcK-NFE2L2:ATF4ATF4SLC7A11H+ATPPPiADP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025