Regulation of MITF-M-dependent genes involved in pigmentation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ATPADPpT153 USF1 dimerUSF1 dimerMITF-M dimerM-MITF dimer:BAF complex:TYR geneBAF complexTYR geneIRF4 geneIRF4IRF4:TYR geneTYRDCT geneDCTTYRP1 geneTYRP1GPR143 geneOA1MITF-M dimer:PMEL genePMEL genePMEL alpha:PMEL betaMLANA geneMLANARAB27A geneGGC-RAB27AMYO5A geneMYO5A dimerp-S1652-MYO5A dimerGGC-RAB27A:MLPH,MYRIP:SYTL2:p-S1652-MYO5A dimerSYTL2MLPH,MYRIPATPADPpT153 USF1 dimer:TYR promoterMITF-M dimer:TFAP2A:IRF4 geneTFAP2A homodimerSOX10MITF-M dimer:SOX10:p-S133 CREB1:LEF1:CTNNB1:DCT genep-S133-CREB1LEF1:CTNNB1MITF-M dimer:BAF complex:TYRP1 geneMITF-M dimer:GPR143 geneMITF-M dimer:MLANA geneMITF-M dimer:RAB27A geneMITF-M dimer:MYO5A gene
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 27 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14497 AT-rich interactive domain-containing protein 1A
  • ARID1A
  • BAF250
  • BAF250A
  • C1orf4
  • OSA1
  • SMARCF1
view
O96019 Actin-like protein 6A
  • ACTL6A
  • BAF53
  • BAF53A
  • INO80K
view
P05549 Transcription factor AP-2-alpha
  • AP2TF
  • TFAP2
  • TFAP2A
view
P14679 Tyrosinase
  • TYR
view
P17643 5,6-dihydroxyindole-2-carboxylic acid oxidase
  • CAS2
  • TYRP
  • TYRP1
  • TYRRP
view
P31751 RAC-beta serine/threonine-protein kinase
  • AKT2
view
P35222 Catenin beta-1
  • CTNNB
  • CTNNB1
view
P40126 L-dopachrome tautomerase
  • DCT
  • TYRP2
view
P40967 Melanocyte protein PMEL
  • D12S53E
  • PMEL
  • PMEL17
  • SILV
view
P51531 Probable global transcription activator SNF2L2
  • BAF190B
  • BRM
  • SMARCA2
  • SNF2A
  • SNF2L2
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025