Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Antigen:p-BCRAntigen:p-BCR:SYKSYKAntigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2ADPATPAntigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2BLNK (SLP-65) SignalosomeAntigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2PIK3CD:PIK3R1CD19 Signalosomep-CD19:VAV1Ash-LPIP2PIP3TRPC1STIM1:TRPC1STIM1 DimerCRAC channelORAI dimerIP3ITPR:I(1,4,5)P3 tetramerIP3 receptor homotetramerBCRAntigen:BCRAntigenAntigen:p-BCR:p-SYKBLNK:GRB2:SOS1:CIN85Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1VAV1PLCG2NCK1BTKCD19:VAV1PIK3AP1BCAP Signalosomep-BAM32:PIP3DAPP1p-Y139-DAPP1:PLCG2:PIP3DAGSTIM1:CalciumCa2+Ca2+Ca2+CALM1CALM1:4xCa2+BTK inhibitorsBTK:BTK inhibitors
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025