Transcriptional and post-translational regulation of MITF-M expression and activity

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
FOXD3 geneFOXD3PAX3:FOXD3PAX3SOX10:PAX3:MITF geneMITF geneSOX10p-S133-CREB1p-S133-CREB1:MITF geneSOX2SOX2:MITF geneAXL3:MITF geneALX3POU3F2POU3F2:MITF geneMITF-MLEF1:CTNNB1:MITF-M:MITF geneCTNNB1LEF1MITF dimerMITF,TFE3,TFEB,TFECATPSOX10_HUMANADPbHLHe32bHLHe32XPO1p-S69,73 MITF-M:XPO1XPO1bHLHe32bHLHe32p-S397,401,405,409 MITF-MSNAI2 geneSNAI2TBX3TBX3_HUMANCDH1 genep-S742 TBX3:CDH1 geneSNAI2:CDH1 geneCDH1ID1 Genep-S742 TBX3:ID1 geneID1multisynthetase complexKARS-depleted MSCATPADPp-S207 KARS homodimerp-S207 KARS dimerAc-CoACoAAc-K21, K30 HINT1 dimerHINT1 dimerH2ONAMNAD2'-O-acetyl-ADP-ribosePPiA(5')p4(5')AH+MITF-M:HINT1 dimerMITF-M:HINT1:p-S207 KARS dimerMITF-M:p-S207 KARS dimerHINT1 dimer:A(5')p4(5')A
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025