Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Hif1aCO2O2Hif1a2OGSUCCAHif3aHif3aO2SUCCAHif1a2OGCO2Hif1aHif3aHif3ahydroxyPro-HIF-alphahydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1VHL:EloB,C:CUL2:RBX1hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1hydroxyPro-HIF-alphaub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3UBE2D1,2,3:UbiquitinUBE2D1,2,3ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1UBE2D1,2,3:UbiquitinUBE2D1,2,3ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1)VBC complex (with or without LIMD1)Ub
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 3 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_004974 Q91YE3 Egl nine homolog 1 view
GL_005018 Q91YE2 Prolyl hydroxylase EGLN2 view
GL_005032 Q91UZ4 Prolyl hydroxylase EGLN3 view
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.1.1

Last updated: February 17, 2025