Macroautophagy

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Active mTORC1 complexMTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101ULK1:ATG13:RB1CC1:ATG101ATPADPMTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101mTORC1:Ragulator:Rag:GNP:RHEB:GDPp-S758-ULK1:ATG13:RB1CC1:ATG101mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTPPip-AMPK heterotrimer:AMPp-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101DLCsAMBRA1:DYNLL1,DYNLL2Ambra1AMBRA1:DYNLL1,DYNLL2:BECN1 complexBECN1 complexBECN1 complex:p-AMBRA1:DYNLL1,DYNLL2A2AH22p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101Beclin-1 complexATG14:PIK3C3:PIK3R4:p-S15-BECN1PIPI3PATG14:PIK3C3:PIK3R4:p-S15-BECN1PI3PWIPI1,WIPI2,(WDR45,WDR45B):PI3PWIPI1,WIPI2,(WDR45,WDR45B)Atg12ATG12:ATG7 dimerATG7 dimerATG12:ATG7:CysO572-ATG7Atg10ATG12:ATG7:CysO572-ATG7:ATG10Atg5ATG12:GlyK166-ATG10:ATG5ATG12:GlyK166-ATG10ATG10:GlyK130-ATG5:ATG12GlyK130-ATG5:ATG12WIPI2:PI(3,5)P2ATG16L1 complex:WIPI2:PI(3,5)P2ATG16L1 complexLC3 family precursorsLC3 familyCysO572-ATG7-LC3:ATG7Atg3CysO572-ATG7-LC3:ATG7:ATG3CysO264-ATG3-LC3:ATG7 dimerAtg3LC3:PEPELC3:PE
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025