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Nonhomologous End-Joining (NHEJ)

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Mus musculus
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Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complexBRERif1DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1BRCC3Paxip1Babam1UIMC1p-5S-BRCA1:p-2T-BARD1Q8BPZ8RNF8:Zn2+XRCC5:XRCC6P70399Rnf168Q62388K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosomep-5T-MDC1XRCC5:XRCC6:DNA DSBsUBE2N:UBE2V2PIAS4Q4U2R1Q8BVE8Kat5p-MRNPRKDC:XRCC5:XRCC6:DNA DSB endsPrkdcDNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1CQ8K4J0ATPQ8K4J0ADPp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB endsp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Ligatable DNA DSB endsPOLL,POLMp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB endsXRCC4:LIG4NHEJ1dNTPp-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB endsPPi
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 11 - 18 of 18 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
Q64478 Histone H2B type 1-H
  • H2bc9
  • Hist1h2bh
 view
Q64524 Histone H2B type 2-E
  • H2bc21
  • Hist2h2be
 view
Q6ZWY9 Histone H2B type 1-C/E/G
  • H2bc4
  • H2bc6
  • H2bc8
  • Hist1h2bc
  • Hist1h2be
  • Hist1h2bg
 view
Q8BJ37 Tyrosyl-DNA phosphodiesterase 1
  • Tdp1
 view
Q8CGP0 Histone H2B type 3-B
  • H2bc26
  • H2bc26-ps
  • H2bu1
  • H2bu1-ps
  • Hist3h2bb
  • Hist3h2bb-ps
 view
Q8CGP1 Histone H2B type 1-K
  • H2bc12
  • Hist1h2bk
 view
Q8CGP2 Histone H2B type 1-P
  • Hist1h2bp
 view
Q9D2M8 Ubiquitin-conjugating enzyme E2 variant 2
  • Mms2
  • Ube2v2
  • Uev2
 view
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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: April 7, 2025