RNA Polymerase II Pre-transcription Events

Summary
Species
Mus musculus
Reactome
PubChem
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pol II transcription complexTFIIDGTF2Btemplate DNA with first transcript dinucleotide, opened to +8 positionTFIIETFIIARNA Polymerase II (unphosphorylated):TFIIF complexTFIIHpol II transcription complex containing 4-9 nucleotide long transcripttemplate DNA:4-9 nucleotide transcript hybridPol II Promoter Escape ComplexDNA containing Pol II promoter with transcript with 2 or 3 nucleotidesP63271DSIF complexO55201ElobElongin B:C complexElocSsrp1FACT complexQ920B9NelfcdNELF complexNelfeNelfaNelfbCCNT1,CCNT2,CCNKP-TEFb complexCDK9EloaElongin ComplexPaused processive elongation complexProcessive elongation complexDSIF:NELF:early elongation complexAborted elongation complex after arrestSupt6hPAF1CNTPEaf2Mllt1RNA Polymerase II holoenzyme complex (hyperphosphorylated)Ctdp1Eaf1TCEA1EllMllt3Iws1Aff4TFIIFdamaged DNA substrate:nascent mRNA hybridpol II open pre-initiation complexpol II closed pre-initiation complex
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025