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MIRAGE
Interleukin-4 and Interleukin-13 signaling

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Il2rgIL2RG:JAK3JAK3JAK3 inhibitorsJAK3:JAK3 inhibitorsIl4rIL4R:JAK2JAK2TYK2IL13RA1:TYK2O09030Il4IL4:IL4R:JAK2IL4:IL4R:JAK2:IL2RG:JAK3IL4:IL4R:JAK2:IL13RA1:TYK2IL4:IL4R:JAK2:IL2RG:JAK3:JAK1JAK1ATPADPIL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6STAT3,STAT6IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6p-Y705-STAT3,p-Y641-STAT6p-Y705-STAT3 dimer, p-Y614-STAT6 dimerp-Y705-STAT3 dimer, p-Y641-STAT6 dimerIL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1)SOCS5,(SOCS1)O88786IL13:IL13RA2Il13IL13:IL13RA:TYK2IL13:IL13RA:TYK2:IL4R:JAK2IL13:IL13RA:TYK2:IL4R:JAK2:JAK1IL13-bound tyrosine-phosphorylated IL13R type IIIL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6STAT1,STAT3,STAT6IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6p-Y701-STAT1,p-Y705-STAT3,p-Y641-STAT6p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimerp-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025