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Regulation of TP53 Degradation

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
H2Op-S166,S188-MDM2:p-S346,S367,S403-MDM4USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4USP2PolyUbMdm2Mdm2P23804ATPADPQ9WVC6Sgk1Q9WVC6P23804p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4p-S166,S188-MDM2,MDM4p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53TP53 TetramerPolyUb-TP53 TetramerUbPolyUb-TP53 Tetramerp-S166,S188-MDM2 dimerPolyUb,p-S166,S188-MDM2 homodimerATPP23804ADPp-S166,S188-MDM2:MDM4p-S166,S188-MDM2:p-S403-MDM4PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4PolyUb,p-S166,S188-MDM2:(PolyUb,p-S166,S188-MDM2, PolyUb,p-S342,S367,S403-MDM4)DAXX:(PolyUb,p-S166,S188-MDM2):USP7Usp7Daxxp-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4)P23804PP2A-PPP2R5CPPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2)Ccng1PiPolyUb,p-S15,S20-TP53 Tetramerp-S15,S20-TP53 Tetramer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025