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MIRAGE
Formation of the cornified envelope

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
EvplEVPL:PPLPplCell surfaceEVPL:PPL:Cell surfaceFLG(?-?):Keratin tonofilament:DesmosomeFLG-Keratin filament networkLamellar bodyCornified envelopeEarly cornified envelopeCdsnCornified envelope:CDSNLate cornified envelopeMature cornified envelopeMature cornified envelopePerpDesmosome:PERPDesmosomeKaznKAZN:PPLSpink5KLK5:SPINK5Klk5H2OCela2aCela2aCela2aKlk8Klk8Klk8Spink6KLK12:SPINK6Klk12KLK13:SPINK6Klk13KLK14:SPINK6Klk14KLK5:SPINK6SPINK9KLK5:SPINK9RCOOHTAGsDAG
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 1 - 10 of 21 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O35902 Desmoglein-3
  • Dsg3
 view
O55111 Desmoglein-2
  • Dsg2
 view
P55292 Desmocollin-2
  • Dsc2
  • Dsc3
 view
P55849 Desmocollin-1
  • Dsc1
 view
P55850 Desmocollin-3
  • Dsc3
 view
P97347 Repetin
  • Rptn
 view
P97350 Plakophilin-1
  • Pkp1
 view
Q02257 Junction plakoglobin
  • Jup
 view
Q148R4 Serine peptidase inhibitor, Kazal type 5
  • Spink5
 view
Q3U4B4 Lipase member N
  • Lipl4
  • Lipn
 view
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025