Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
UbcUbiquitin (Ubc 2)Ubiquitin (Ubc 3)Ubiquitin (Ubc 1)UbbUbiquitin (Ubb 4)UbbUbiquitin (Ubb 1)UbbUbiquitin (Ubb 3)UbbUbiquitin (Ubb 2)UbbUbbUba52Ubiquitin (Uba52)Uba52Rps27aUbiquitin (Pps27a)Rps27aATPUBA1:ubiquitin adenylatePPiUBA1UbUb-Cys632-UBA1AMPUb-Cys632-UBA1:ubiquitin adenylateUb:E2 (UBA1 substrate)E2 ubiquitin conjugating enzyme (UBA1 substrate)Ub-Cys625-UBA6:ubiquitin adenylateUBA6:ubiquitin adenylateE2 ubiquitin conjugating enzyme (UBA6 substrate)Ub:E2 (UBA6 substrate)ATPUBA1:ubiquitin adenylateUbPPiUBA1Ub-Cys632-UBA1AMPUb-Cys632-UBA1:ubiquitin adenylateUb:E2 (UBA1 substrate)E2 ubiquitin conjugating enzyme (UBA1 substrate)
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 6 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P0CG49 Polyubiquitin-B
  • Ubb
view
P70398 Ubiquitin carboxyl-terminal hydrolase 9X
  • Fafl
  • Fam
  • Usp9x
view
Q02053 Ubiquitin-like modifier-activating enzyme 1
  • Sbx
  • Uba1
  • Ube1
  • Ube1ax
  • Ube1x
view
Q6A4J8 Ubiquitin carboxyl-terminal hydrolase 7
  • Hausp
  • Usp7
view
Q8C7R4 Ubiquitin-like modifier-activating enzyme 6
  • Uba6
  • Ube1l2
view
Q8CFI2 Ubiquitin-conjugating enzyme E2 R1
  • Cdc34
  • Ubch3
  • Ube2r1
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025