Interferon alpha/beta signaling

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
IFNAR2:JAK1:STAT2IFNA/B:IFNAR2:JAK1:STAT2IFNA/Btype 1 interferon analogsIFNAR2:JAK1:STAT2:type 1 interferon analogsIFNAR2:JAK1:STAT2:JAK1,2 inhibitorsJAK1,2 inhibitorsIFNAR1:TYK2IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2IFNAR1:TYK2:TYK2 inhibitorsTYK2 inhibitorsADPATPIFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2Stat2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1p-STAT2:p-STAT1ISGF3Irf9p-Y701-STAT1-1 dimerStat1Kpna1p-STAT1 dimer:KPNA1p-STAT1 dimer, ISGF3p-STAT1 dimer:KPNA1:KPNB1Kpnb1ISGF3:KPNA1:KPNB1Kpna1Kpnb1ISGF3p-Y701-STAT1:KPNA1:KPNB1p-Y701-STAT1 dimerABCE1ABCE1:RNASEL dimerRNASEL dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 18 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O35664 Interferon alpha/beta receptor 2
  • Ifnar2
view
P01572 Interferon alpha-1
  • Ifna1
view
P01573 Interferon alpha-2
  • Ifna2
view
P01575 Interferon beta
  • Ifb
  • Ifnb
  • Ifnb1
view
P06799 Interferon alpha-7
  • Ifa7
  • Ifna7
view
P07349 Interferon alpha-5
  • Ifna5
view
P07350 Interferon alpha-6
  • Ifa6
  • Ifa8
  • Ifna6
  • Ifna8
view
P07351 Interferon alpha-4
  • Ifna4
view
P09235 Interferon alpha-9
  • Ifa9
  • Ifna9
view
P0CG49 Polyubiquitin-B
  • Ubb
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025