Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Translated mRNA Complex with Premature Termination Codon Preceding Exon JunctionSMG1:UPF1:EJC:Translated mRNPSMG1:SMG8:SMG9 ComplexUPF1ATPSMG1:Phosphorylated UPF1:EJC:Translated mRNPADPPnrc2Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNPSmg5Dcp1aPP2A (Aalpha:B55alpha:Calpha)SMG6Smg7mRNA Cleaved by SMG6Eif4g1Cap Binding Complex (CBC)Pabpc1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025