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MIRAGE
Regulation of TNFR1 signaling

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
TNF(1-76) trimerTnfTnfTNF-α trimer:TNF-R1 trimerTNF-α:TNFR1:DENN-SV,MADDMaddTraf1TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1TraddTraf2Ripk1Traf1Traf1TRADD:TRAF2:RIPK1:FADDTRAF2:TRADD:RIPK1(325-671):FADDRipk1TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L)CflarCasp8CflarTRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L)TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L)CHUK:IKBKB:IKBKGIKKA:IKKB:NEMO:GNB2L1Rack1TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3TAX1BP1:TNFAIP3K48polyUbK48polyUb-RIPK1-containing TNFR1 complexesRIPK1-containg TNFR1 signaling complexesUbTNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3Ub:UBE2L3Ube2l3TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBACTNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBACCYLD:SPATA2:LUBACTNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLDTNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLDBIRC2,3,4TNF-α:TNFR1:TRADD:RIPK1:TRAF2Ub:UBE2D3RIPK1:STUB1:Ub:UBE2D3STUB1:STUB1Ube2d3Ripk1Ub:UBE2D1TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1MIB2Ube2d1TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2MIB2:CYLD:UBE2D2Ub:UBE2D2CYLDQ66H62CFLAR:MIB2:Ub:UBE2D1CflarTRAF2:TRADD:RIPK1TRAF2:TRADD:p-S320-RIPK1ADPATPTNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKETBK1, IKBKETNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKETRAF2:TRADD:p-S357-RIPK1TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKGTNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKGQ66H62TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBACTNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTNOPTNCYLD:OPTN:polyUb-RIPK1:TNFR1 complexOPTN:CASP8
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 4 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
A0A8I6AL23 ubiquitinyl hydrolase 1
  • Tnfaip3
 view
P16599 Tumor necrosis factor
  • Tnf
  • Tnfa
  • Tnfsf2
 view
P22934 Tumor necrosis factor receptor superfamily member 1A
  • Tnfr-1
  • Tnfr1
  • Tnfrsf1a
 view
Q5PQL3 Signal peptide peptidase-like 2B
  • Sppl2b
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025