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MIRAGE
MAP2K and MAPK activation

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p21 RAS:GTP:activated RAF homo/heterodimer complexesactivated RAF:scaffold:MAP2K:MAPK complexMAP2K homo/heterodimersRAF/MAPK scaffoldsMAPKsdual mechanism MAP2K1/2 inhibitorsactivated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitorsADPATPactivated RAF:scaffold:p-2S MAP2K:MAPK complexsingle mechanism MAP2K1/2 inhibitorsactivated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitorsdual mechanism MAPK inhibitorsactivated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitorsactivated RAF:scaffold:p-2S MAP2K:p-2T MAPK complexp-2S MAP2K homo/heterodimersp21RAS:GTP:activated RAF homo/heterodimersp-T,Y MAPKsactivated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitorssingle mechanism MAPK inhibitorsWDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complexWDR83:LAMTOR2:LAMTOR3activated RAF homo/heterodimerWDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complexIl17rdIL17RD:p-2S MAP2Ks:MAPKsIL17RD:p-2S MAP2Ks:p-T,Y MAPKs
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 6 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P02680 Fibrinogen gamma chain
  • Fgg
 view
P04937 Fibronectin
  • Fn1
 view
P06399 Fibrinogen alpha chain
  • Fga
 view
P14480 Fibrinogen beta chain
  • Fgb
 view
P36506 Dual specificity mitogen-activated protein kinase kinase 2
  • Map2k2
  • Mek2
  • Mkk2
  • Prkmk2
 view
Q8R2H2 Integrin beta-3
  • Itgb3
 view
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025