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MIRAGE
Interleukin-1 signaling

Summary
Species
Rattus norvegicus
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PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MAP2K6ADPATPQ925D6Interleukin-1IL1B,Myr82K-Myr83K-IL1A:IL1R1Il1r1IL1R1:IL1R1 inhibitorsIL1R1 inhibitorsIL1B,Myr82K-Myr83K-IL1A:IL1R2Il1r2IL1R1:IL1R2IL1R1:IL1R2:IL1RNIl1rnIL1R1:IL1:IL1RAPIl1rapMYD88 dimerIL1R1:IL1:IL1RAP:MYD88 dimerIRAK4IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimerIL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIPTollipIL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIPQ4QQS0IRAK2IRAK1IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6Traf6MAP3K3:SQSTM1:TRAF6MAP3K3:SQSTM1A0A8I6G1H3p-2S,S376,T,T209,T387-IRAK1:TRAF6hp-IRAK1:3xTRAF6hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUbhp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1TAK1 complexhp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complexhp-IRAK1:3xK63polyUb-TRAF6hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complexhp-IRAK1, IRAK4hp-IRAK1:Pellino, IRAK4:PellinoPellino 1,2,3hp-IRAK1:p-Pellino, IRAK4:p-Pellinohp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUbK63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1CHUK:IKBKB:IKBKGPoly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKGA0A0G2JYX9Q63746NfkbiaUbBTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:UbNFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025