GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **251 - 275** of **557** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism	GlyTouCan ID
Regulation of TP53 Activity through Phosphorylation	5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-3 ATRIP protein Acetyl-CoA carboxylase kinase Aurora kinase A Aurora kinase BRCA1 associated RING domain 1 BRCA1 interacting helicase 1 Breast cancer type 1 susceptibility protein homolog Casein kinase II subunit alpha Casein kinase II subunit alpha Casein kinase II subunit beta Cell cycle checkpoint control protein Cell cycle checkpoint control protein Cellular tumor antigen p53 Checkpoint kinase 2 Checkpoint protein Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 DNA 3'-5' helicase DNA 3'-5' helicase DNA endonuclease RBBP8 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase II binding protein 1 DNA topoisomerase Double-strand break repair protein E3 ubiquitin-protein ligase Mdm2 Exonuclease 1 FACT complex subunit SSRP1 FACT complex subunit Histone acetyltransferase Homeodomain interacting protein kinase 1 Homeodomain interacting protein kinase 2 MAPK activated protein kinase 5 Mitogen-activated protein kinase 11 Nibrin Nucleolar complex protein 2 homolog Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Polyubiquitin-B Polyubiquitin-C Protein kinase AMP-activated non-catalytic subunit beta 2 Protein kinase AMP-activated non-catalytic subunit gamma 2 RAD1 checkpoint DNA exonuclease RAD17 protein RAD50 double strand break repair protein RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ mediated genome instability 2 RecQ-mediated genome instability protein 1 Replication factor A protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 5 Replication protein A subunit Replication protein A3 Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase PLK TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa TATA-box binding protein associated factor 15 TATA-box binding protein associated factor 3 TATA-box binding protein associated factor 4 TATA-box binding protein associated factor 4b TATA-box binding protein associated factor 5 TATA-box binding protein associated factor 7 like TATA-box binding protein associated factor 9b TATA-box-binding protein TPX2 microtubule nucleation factor Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 9 Transcription initiation factor TFIID subunit Tumor protein p53 inducible nuclear protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein dual-specificity kinase mitogen-activated protein kinase non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	A0A3Q1LTT9 A0A3Q1LWE4 A0A3Q1LY33 A0A3Q1M8V1 A0A3Q1MBC1 A0A3Q1MEP0 A0A3Q1MHM3 A0A3Q1MIR9 A0A3Q1MJD6 A0A3Q1MS65 A0A3Q1MSS5 A0A3Q1NLY2 A0A3S5ZPW0 A4IF98 A5D7S1 A5PJW1 A5PK80 A6QNK6 A6QQT5 E1B986 E1B9B6 E1BB72 E1BCU9 E1BEE6 E1BEI6 E1BEN8 E1BF15 E1BG06 E1BG90 E1BGK7 E1BGX1 E1BIA9 E1BIN9 E1BMP7 E1BNP8 E1BQ04 E1BQ34 F1MAV4 F1MBG5 F1MFW1 F1MGY1 F1MH23 F1MJ55 F1MK86 F1MME0 F1MMS0 F1MMS1 F1MQV7 F1MVR8 F1MYE6 F1MYX8 F6PSE2 F6R5E4 G3MWV4 G3N1E6 G3X6W2 G3X793 G8JKW1 P0CG53 P0CH28 P58108 P62992 P63048 P67868 P67939 P68399 Q02399 Q05B83 Q08DN4 Q0VCE7 Q0VCV0 Q17QQ4 Q1LZE2 Q28199 Q2HJ52 Q2KI86 Q2LL38 Q2TA06 Q2TBV1 Q3SYU1 Q3SZ11 Q3T174 Q3ZBP7 Q5BIN5 Q5BIS9 Q5E9Y0	AIK AIRK1 ARK1 ATM ATR ATRIP AURA AURKA AURKB AYK1 BARD1 BLM BRCA1 BRIP1 BTAK CCNA1 CCNA2 CDK2 CDK5 CDK5R CDK5R1 CDKN2 CDKN5 CHEK2 CK2A1 CK2N CSNK2A1 CSNK2A2 CSNK2B DNA2 DYRK2 EXO1 HIPK1 HIPK2 HUS1 IAK1 KAT5 MAPK11 MAPK14 MAPKAPK5 MDM2 MRE11 NBN NCK5A NIR NOC2L NUAK1 PIN1 PLK3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PSSALRE RAD1 RAD17 RAD50 RAD9A RAD9B RBBP8 RFC2 RFC3 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 RPS27A SSRP1 STK11 STK15 STK6 SUPT16H TAF1 TAF10 TAF11 TAF12 TAF15 TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF7L TAF9 TAF9B TBP TOP3A TOPBP1 TP53 TP53INP1 TP53RK TPX2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WRN	Bos taurus (cattle)
ADP signalling through P2Y purinoceptor 1	Cytosolic phospholipase A2 G protein subunit beta 3 G protein subunit gamma 13 GNB4 protein Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma P2Y purinoceptor 1 Tyrosine-protein kinase mitogen-activated protein kinase	A0A3Q1LTT9 A0A3Q1NGS8 A0A3S5ZPL0 A4IFJ5 A4IFL6 A5PKD6 E1B8Q3 E1BA29 E1BIM8 F1MYW8 F1N2V3 P02698 P11017 P30671 P38408 P38409 P48042 P50154 P62871 P63212 P63214 P63217 Q28024 Q3SZ98 Q5E9F0	CPLA2 GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT12 GNGT2 GNGT3 GNGT5 GNGT7 GNGT8 MAPK14 P2RY1 PLA2G4 PLA2G4A SRC	Bos taurus (cattle)
TCF dependent signaling in response to WNT	Axin 2 Axin-1 Catenin beta-1 E3 ubiquitin-protein ligase RNF146-B Poly [ADP-ribose] polymerase Poly [ADP-ribose] polymerase Polyubiquitin-B Polyubiquitin-C Protein Wnt Protein Wnt Protein Wnt Protein Wnt Ubiquitin specific peptidase 34 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A3Q1LTW2 A0A3Q1M230 A0A3Q1MDV7 E1B8R5 E1BDG5 E1BEN9 F1N5R1 G3X7P3 M5FK80 P0CG53 P0CH28 P62992 P63048 Q0VCX4 Q3T139	AXIN1 AXIN2 CTNNB1 RNF146B RPS27A TNKS TNKS2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP34 WNT1 WNT3 WNT3A WNT5A	Bos taurus (cattle)
Regulation of FZD by ubiquitination	Frizzled class receptor 5 Frizzled class receptor 8 Frizzled-6 Leucine rich repeat containing G protein-coupled receptor 5 Low-density lipoprotein receptor-related protein Low-density lipoprotein receptor-related protein Polyubiquitin-B Polyubiquitin-C Protein Wnt R-spondin 1 R-spondin 2 R-spondin 4 R-spondin-3 RING-type E3 ubiquitin transferase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1	A0A3Q1LTW2 A0A3Q1MA92 A0A452DIK6 E1BNT4 F1MDE1 F1ME23 F1MGM1 F1MH47 F1MP23 F1N1K8 F6RLD1 P0CG53 P0CH28 P62992 P63048 Q0IIM6 Q1RMU1	FZD5 FZD6 FZD8 LGR5 LRP5 LRP6 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP8 WNT3A	Bos taurus (cattle)
Chemokine receptors bind chemokines	Atypical chemokine receptor 2 Atypical chemokine receptor 3 Atypical chemokine receptor 4 C motif chemokine ligand 1 C-C chemokine receptor type 5 C-C motif chemokine 20 C-C motif chemokine 2 C-C motif chemokine 4 C-C motif chemokine 5 C-C motif chemokine ligand 1 C-C motif chemokine ligand 21 C-C motif chemokine ligand 27 C-C motif chemokine receptor 10 C-C motif chemokine receptor 3 C-C motif chemokine receptor 4 C-C motif chemokine receptor 6 C-C motif chemokine receptor 8 C-C motif chemokine C-C motif chemokine C-C motif chemokine C-C motif chemokine C-C motif chemokine C-C motif chemokine C-X-C chemokine receptor type 2 C-X-C chemokine receptor type 2 C-X-C chemokine receptor type 3 C-X-C chemokine receptor type 4 C-X-C chemokine receptor type 6 C-X-C motif chemokine 10 C-X-C motif chemokine 11 C-X-C motif chemokine 16 C-X-C motif chemokine 6 C-X-C motif chemokine 9 C-X-C motif chemokine receptor 5 C-X-C motif chemokine C-X-C motif chemokine C-X-C motif chemokine CCL25 protein CCR9 protein CX3C chemokine receptor 1 Chemokine (C-C motif) receptor 1 Chemokine C-C motif receptor-like 2 Chemokine interleukin-8-like domain-containing protein Eotaxin Growth-regulated protein homolog beta Growth-regulated protein homolog gamma Interleukin-8 Stromal cell-derived factor 1 X-C motif chemokine receptor 1	A0A3Q1LTZ4 A0A3Q1M085 A0A3Q1MHN9 A0A3Q1NB11 A0JN72 A4IF77 A4IF92 A5PKF1 A6QLA5 A6QNL7 A6YT15 A9QWP9 A9QWQ1 D9ZDE4 E1BAG6 E1BGB8 E1BH62 F1MD23 F1MD83 F1MP16 F1MT56 F1MYS4 F1MZ86 F1N2D2 F1N4S8 F6RDR3 G3N3U0 G5E6Q0 O46675 O46677 O97919 P25930 P28291 P35350 P79255 P80221 Q0II78 Q17QA1 Q1RMQ0 Q29RT9 Q2HJ17 Q2KIQ8 Q3ZBN3 Q56JW7 Q5EA94 Q5MD61 Q8SQB1 Q9BDJ2 Q9TTS6	ACKR2 ACKR3 ACKR4 CCL1 CCL11 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL4 CCL5 CCR1 CCR10 CCR11 CCR3 CCR4 CCR5 CCR6 CCR8 CCR9 CCRL1 CCRL2 CMKBR5 CX3CR1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL3 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 GCP2 IL8 LOC100297044 LOC525415 LOC616364 MIP3A PPBP SCY4A SCYA2 SCYA20 SCYA5 SCYB6 XCL1 XCL2 XCR1	Bos taurus (cattle)
Assembly of active LPL and LIPC lipase complexes	Angiopoietin like 8 Angiopoietin-like 3 Angiopoietin-related protein 4 Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 Hepatic triacylglycerol lipase Lipase maturation factor Lipase maturation factor Lipoprotein lipase Proprotein convertase subtilisin/kexin type 5 Proprotein convertase subtilisin/kexin type 6 furin	A0A3Q1LU66 A0A3Q1MCD7 A0A3Q1MPP4 B0JYR0 E1BKI5 F1MCT1 G3X879 P11151 Q2KJ51 Q2KJB3 Q3SZ79	ANGPTL3 ANGPTL4 ANGPTL8 FURIN GPIHBP1 LIPC LMF1 LMF2 LPL PCSK5 PCSK6	Bos taurus (cattle)
Lewis blood group biosynthesis	Alpha-(1,3)-fucosyltransferase 7 Alpha-(1,3)-fucosyltransferase Alpha-(1,3)-fucosyltransferase Beta-1,4-N-acetyl-galactosaminyltransferase 2 Fucosyltransferase Fucosyltransferase Fucosyltransferase Hexosyltransferase Hexosyltransferase L-Fucosyltransferase ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Type 2 lactosamine alpha-2,3-sialyltransferase	A0A3Q1LUC6 A0A3Q1MGH3 A0A452DJH9 E1BIT9 F1MBS8 F1MDG4 F1MUS1 F1MWE7 F1N557 F1N751 G3MZR2 Q2HJA3 Q3T0R9 Q6H8M7	B3GALT2 B3GALT4 B4GALNT2 FUT10 FUT11 FUT2 FUT4 FUT6 FUT7 FUT9 SIAT10 ST3GAL3 ST3GAL4 ST3GAL6 ST6GALNAC6	Bos taurus (cattle)	G39211DH G81971FM G83633HB G90387AM G98173LG
Glycosphingolipid biosynthesis	Beta-1,4 N-acetylgalactosaminyltransferase Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Ceramide kinase Gal-NAc6S Galactoside alpha-(1,2)-fucosyltransferase 1 Hexosyltransferase Hexosyltransferase L-Fucosyltransferase Lactosylceramide 4-alpha-galactosyltransferase Lactosylceramide alpha-2,3-sialyltransferase ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 UDP glycosyltransferase 8 ceramide glucosyltransferase	A0A3Q1LUC6 A0A3Q1MPZ8 A0A452DJH9 A4IFB0 E1BCQ2 F1MUJ7 F1MUS1 F1MXN8 F1N2J4 F1N7G6 F6Q1T7 G3MXL8 G3MZ03 Q08DR4 Q2HJA3 Q58DI2 Q6H8M9	A4GALT B3GALT4 B3GNT5 B4GALNT1 B4GALT5 B4GALT6 CERK FUT1 FUT2 GALGT ST3GAL2 ST3GAL3 ST3GAL5 ST6GALNAC5 ST6GALNAC6 ST8SIA5 UGCG UGT8 siat4B	Bos taurus (cattle)
FRS-mediated FGFR1 signaling	FRS3 protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase NRas Growth factor receptor-bound protein 2 Klotho SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 A5D7R9 A6H792 D8KXU9 E1B7I9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BMX0 E1BP37 F1N339 F1N6G8 F1N7C3 G3MXR4 G3XGD3 P03968 P03969 Q3T0F9	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 FRS2 FRS3 Fgf4 GRB2 HBGF-1 KL KRAS NRAS PTPN11 SOS1	Bos taurus (cattle)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase NRas Growth factor receptor-bound protein 2 Klotho SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 A5D7R9 D8KXU9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BMX0 E1BP37 F1N6G8 F1N7C3 G3MXR4 G3XGD3 P03968 P03969 Q0IIE2 Q3T0F9	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 Fgf4 GRB2 HBGF-1 KL KRAS NRAS SHC1 SOS1	Bos taurus (cattle)
PI-3K cascade:FGFR1	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Klotho Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 A6QLU3 D8KXU9 E1B7I9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1N339 F1N6G8 G3MXR4 G3XGD3 P03968 P03969 P23727 P32871 Q3T0F9	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 FRS2 Fgf4 GAB1 GRB2 HBGF-1 KL PIK3CA PIK3R1 PTPN11	Bos taurus (cattle)
Downstream signaling of activated FGFR1	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibronectin leucine rich transmembrane protein 1 Fibronectin leucine rich transmembrane protein 2 Fibronectin leucine rich transmembrane protein 3 Klotho	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 D8KXU9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MVT1 F1N0R7 F1N6G8 G3MXR4 G3MY74 G3XGD3 P03968 P03969	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 FLRT1 FLRT2 FLRT3 Fgf4 HBGF-1 KL	Bos taurus (cattle)
Phospholipase C-mediated cascade: FGFR1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 D8KXU9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MYF9 F1N6G8 G3MXR4 G3XGD3 P03968 P03969	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 Fgf4 HBGF-1 KL PLCG1	Bos taurus (cattle)
FGFR1b ligand binding and activation	Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor	A0A3Q1LUE0 A0A3Q1NAV6 E1BGY3 P03968 P03969	AFGF FGF1 FGF10 FGF2 FGF3 FGF5C FGFA FGFR1 HBGF-1	Bos taurus (cattle)
FGFR1c ligand binding and activation	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1LUE0 A0MTF4 D8KXU9 E1BHC1 E1BJU2 E1BP37 F1N6G8 G3MXR4 G3XGD3 P03968 P03969	AFGF FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF4A FGF5 FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 Fgf4 HBGF-1	Bos taurus (cattle)
FGFR1c and Klotho ligand binding and activation	Fibroblast growth factor 23 Fibroblast growth factor receptor Klotho	A0A3Q1LUE0 E1BAI2 E1BJU2	FGF23 FGFR1 KL	Bos taurus (cattle)
Bicarbonate transporters	Adenosylhomocysteinase 3 Anion exchange protein Anion exchange protein Anion exchange protein Anion exchange protein Anion exchange protein Anion exchange protein Anion exchange protein Anion exchange protein Sodium-driven chloride bicarbonate exchanger	A0A3Q1LUF6 A0A3Q1M051 A6QLP2 E1BBH7 E1BIN2 E1BKK3 F1MVR5 F6QPG2 G3MWI1 Q32LP4	AHCYL2 SLC4A1 SLC4A10 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A7 SLC4A8 SLC4A9	Bos taurus (cattle)
TRAF6 mediated NF-kB activation	Advanced glycosylation end-product specific receptor Amyloid-beta A4 protein High mobility group protein B1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappa-B inhibitor-interacting Ras-like protein 2 NF-kappaB transcription factor p65 subunit NFKB inhibitor interacting Ras like 1 NFKB2 protein Nuclear factor NF-kappa-B p105 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Protein S100-A12 Protein S100-B	A0A3Q1LUG2 A0A3Q1LZM4 A1XG22 A7MBB7 F1MKW9 F1N306 P02638 P10103 P79105 Q0IIB2 Q1JPF1 Q8WNW7 Q95KU9 Q95KV0 Q95KV1	AGER APP CAAF1 CHUK HMG1 HMGB1 IKBKB IKBKG IKKA NEMO NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 RELA S100A12 S100B bIkBa	Bos taurus (cattle)
TAK1-dependent IKK and NF-kappa-B activation	Advanced glycosylation end-product specific receptor Amyloid-beta A4 protein High mobility group protein B1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappa-B inhibitor-interacting Ras-like protein 2 NF-kappaB transcription factor p65 subunit NFKB inhibitor interacting Ras like 1 NFKB2 protein Nuclear factor NF-kappa-B p105 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Protein S100-A12 Protein S100-B	A0A3Q1LUG2 A0A3Q1LZM4 A1XG22 A7MBB7 F1MKW9 F1N306 P02638 P10103 P79105 Q0IIB2 Q1JPF1 Q8WNW7 Q95KU9 Q95KV0 Q95KV1	AGER APP CAAF1 CHUK HMG1 HMGB1 IKBKB IKBKG IKKA NEMO NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 RELA S100A12 S100B bIkBa	Bos taurus (cattle)
SUMOylation of immune response proteins	Inhibitor of nuclear factor kappa B kinase subunit epsilon NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappaB transcription factor p65 subunit NFKB2 protein PIAS3 protein PIAS4 protein RING-type E3 ubiquitin transferase Rad60/SUMO-like domain-containing protein Rad60/SUMO-like domain-containing protein SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 3	A0A3Q1LUL4 A0A3Q1M2W5 A1XG22 A4FV15 A6QQU9 A7MBB7 F1MQ36 F1N329 G3MZL6 Q17QV3 Q8WNW7 Q95KU9	IKBKE IKBKG NEMO NFKB2 NFKBIA PIAS3 PIAS4 RELA SUMO3 TOPORS bIkBa	Bos taurus (cattle)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 CUL2 protein Elongin-C Endothelial PAS domain protein 1 Hypoxia inducible factor 3 subunit alpha Hypoxia-inducible factor 1-alpha LIM domain-containing protein 1 LIM domain-containing protein ajuba Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) Ubiquitin conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WT1 interacting protein hypoxia-inducible factor-proline dioxygenase hypoxia-inducible factor-proline dioxygenase hypoxia-inducible factor-proline dioxygenase	A0A3Q1LUX2 A0A3Q1M2B6 A0A3Q1M5N0 A0A3Q1MIU5 A0A3Q1MKG5 A0A452DI44 A0A452DIY4 A0JND0 A7MBA0 A7MBA2 E1BD83 E1BKA3 E1BP33 F1MBI1 F1MLV1 F1MWE0 F1MXE4 F1MYH8 F1N6Z0 G5E589 G5E5X0 P0CG53 P0CH28 P33672 P56701 P62194 P62992 P63048 Q08DE9 Q17QP9 Q1RMX2 Q2KI42 Q2KII4 Q2KJ25 Q2KJ46 Q2KJE7 Q2TA10 Q2YDE4 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZ32 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0	AJUBA CUL2 EGLN1 EGLN2 EGLN3 ELOC EPAS1 HIF1A HIF3A JUB LIMD1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A SUG1 TCEB1 TCEB2 TRAP2 UBA52 UBA80 UBB UBC UBC4 UBCEP1 UBCEP2 UBCH4 UBCH5B UBE2D1 UBE2D2 UBE2D3 WTIP	Bos taurus (cattle)
Phase 1 - inactivation of fast Na+ channels	Kv channel-interacting protein 4 Potassium voltage-gated channel interacting protein 1 Potassium voltage-gated channel interacting protein 2 Potassium voltage-gated channel interacting protein 3 Potassium voltage-gated channel subfamily D member 1 Potassium voltage-gated channel subfamily D member 2 Potassium voltage-gated channel subfamily D member 3	A0A3Q1LV43 A0A3Q1M5I5 A0A3Q1M784 F1MVI5 F1MY95 Q2KI69 Q52PG9	KCND1 KCND2 KCND3 KCNIP1 KCNIP2 KCNIP3 KCNIP4	Bos taurus (cattle)
Formation of the cornified envelope	Caspase 14 Corneodesmosin DSC1 protein Desmocollin 2 Desmocollin 3 Desmoglein 1 Desmoglein 2 Desmoglein 3 Desmoglein 4 Desmoplakin Envoplakin Junction plakoglobin Kallikrein C Kallikrein related peptidase 12 Kallikrein related peptidase 13 Kallikrein related peptidase 14 Kallikrein related peptidase 8 Lipase family member J Lipase Lipase Lipase Peptidase inhibitor 3, skin-derived (SKALP) Periplakin Plakophilin 1 Plakophilin 4 Protein-glutamine gamma-glutamyltransferase K Repetin Serine peptidase inhibitor Kazal type 5 Serine peptidase inhibitor Kazal type 9 Serine protease inhibitor Kazal-type 6 Trichohyalin pancreatic elastase II	A0A3Q1LV63 A0A3Q1LZM5 A0A3Q1M4I0 A0A3Q1NK79 A1A4Q6 A6QR67 E1B9D7 E1B9N6 E1BA50 E1BE09 E1BGD9 E1BKC5 E1BKT9 E1BM91 E1BNT1 F1MBB7 F1MFC2 F1MGR5 F1MIW8 F1MJ11 F1MJH0 F1MSA3 F1MWJ0 F1MXJ3 F1MXS5 F1MZF2 F1N2K8 G3MVZ9 G3N156 G3X7H1 P01001 Q8SPJ1	CASP14 CDSN CELA2A DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSG4 DSP EVPL JUP KLK12 KLK13 KLK14 KLK5 KLK8 KLNC LIPJ LIPK LIPM LIPN PI3 PKP1 PKP4 PPL RPTN SPINK5 SPINK6 SPINK9 TCHH TGM1	Bos taurus (cattle)
Ion homeostasis	ATP binding cassette subfamily C member 9 ATP-sensitive inward rectifier potassium channel 11 Aspartyl/asparaginyl beta-hydroxylase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calmodulin-like Cardiac phospholamban Chloride intracellular channel 2 EF-hand domain-containing protein FXYD domain-containing ion transport regulator 6 FXYD domain-containing ion transport regulator 7 FXYD domain-containing ion transport regulator FXYD domain-containing ion transport regulator Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Nitric oxide synthase Peptidyl-prolyl cis-trans isomerase FKBP1B Phospholemman Plasma membrane calcium-transporting ATPase 4 Ryanodine receptor 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Short transient receptor potential channel 1 Sodium/calcium exchanger 1 Sodium/potassium-transporting ATPase subunit alpha-1 Sodium/potassium-transporting ATPase subunit alpha-2 Sodium/potassium-transporting ATPase subunit alpha Sodium/potassium-transporting ATPase subunit alpha Sodium/potassium-transporting ATPase subunit beta-3 Sodium/potassium-transporting ATPase subunit beta Sodium/potassium-transporting ATPase subunit beta Solute carrier family 8 member A2 Sorcin Stromal interaction molecule 1 cAMP-dependent protein kinase catalytic subunit alpha calcium/calmodulin-dependent protein kinase	A0A3Q1LV78 A0A3Q1LWV7 A0A3Q1M6M2 A0A3Q1M9U0 A0A3Q1MFU0 A0A3Q1MGH8 A0A3Q1MKC7 A0A3Q1MR28 A0A3Q1N7P8 A0A3Q1ND98 A0A3S5ZPA3 A2VDL6 A2VDS4 A2VE46 A6QLL5 D3K0R6 E1B7D0 E1B8N5 E1BHV1 E1BKE7 E1BMQ6 F1MC36 F1MLH6 F1MN60 F1MR06 F1MS16 F1MX21 F2Z4I4 F6QQY9 G3MWR4 P00517 P68107 Q08DA1 Q0VCY0 Q28056 Q2HJF7 Q3MHJ9 Q3MHZ5 Q3SZX0 Q3T0C6 Q3ZBJ3	ABCC9 ASPH ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM CAMK2A CAMK2B CAMK2D CLIC2 FKBP12.6 FKBP1B FXYD1 FXYD2 FXYD4 FXYD6 FXYD7 ITPR1 ITPR2 ITPR3 KCNJ11 NOS1 PLM PLN PRKACA RYR2 SLC8A1 SLC8A2 SRI STIM1 TRPC1	Bos taurus (cattle)
PI Metabolism	TNF alpha induced protein 8 like 3 Tumor necrosis factor alpha-induced protein 8-like protein 1 Tumor necrosis factor alpha-induced protein 8-like protein 2 Tumor necrosis factor alpha-induced protein 8	A0A3Q1LVF0 A4IF78 A5PK29 Q3ZBK5	TNFAIP8 TNFAIP8L1 TNFAIP8L2 TNFAIP8L3	Bos taurus (cattle)

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