GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **226 - 250** of **268** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Electric Transmission Across Gap Junctions	Gap junction protein Gap junction protein Gap junction protein Pannexin Pannexin	A0A8I3N0E0 A0A8I3N240 A0A8I3N9K8 A0A8I3PDQ2 A0A8I3QZQ9	GJA10 GJC1 GJD2 PANX PANX1 PANX2	Canis familiaris (dog)
Gastrin-CREB signalling pathway via PKC and MAPK	Gastrin/cholecystokinin type B receptor Gastrin Mitogen-activated protein kinase Mitogen-activated protein kinase Mitogen-activated protein kinase Ribosomal protein S6 kinase Ribosomal protein S6 kinase cAMP responsive element binding protein 1 non-specific serine/threonine protein kinase	A0A8I3MV42 A0A8I3NAU2 A0A8I3P721 A0A8I3PZN8 A0A8I3PZP0 A0A8I3RQD0 A0A8I3S2U7 P01353 P30552	CCKBR CREB1 GAS GAST MAPK1 MAPK3 MAPK7 RPS6KA1 RPS6KA2 RPS6KA3	Canis familiaris (dog)
Assembly and cell surface presentation of NMDA receptors	Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor Glutamate receptor Glutamate receptor Glutamate receptor	A0A8I3NNK2 A0A8I3NRD6 A0A8I3P9B8 A0A8I3RRH4 Q5R1P0 Q5R1P3	GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A NMDAR1	Canis familiaris (dog)
N-glycan trimming and elongation in the cis-Golgi	Glycoprotein endo-alpha-1,2-mannosidase	A0A8I3N4I9	MANEA	Canis familiaris (dog)	G58161NS
Signaling by ROBO receptors	Glypican-1 Slit guidance ligand 2 Slit guidance ligand 3	A0A8I3MRE2 A0A8I3NQC4 A0A8I3Q4U0	GPC1 SLIT2 SLIT3	Canis familiaris (dog)
Insulin receptor signalling cascade	Growth factor receptor bound protein 10 Growth factor receptor bound protein 2 Insulin SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase receptor	A0A8I3NBK6 A0A8I3NUU1 A0A8I3PT69 A0A8I3PWD4 A0A8I3S3D9 P01321	GRB10 GRB2 INS INSR SHC1 SOS1	Canis familiaris (dog)
MET Receptor Activation	HGF activator Hepatocyte growth factor receptor Hepatocyte growth factor Hepsin Serine peptidase inhibitor, Kunitz type 1 Serine peptidase inhibitor, Kunitz type 2	A0A8I3MSC1 A0A8I3MW78 A0A8I3NGY1 A0A8I3NIY8 A0A8I3S6Z5 Q867B7	HGF HGFAC HPN MET SPINT1 SPINT2	Canis familiaris (dog)
The NLRP3 inflammasome	Heat shock protein HSP 90-beta MEFV innate immunity regulator, pyrin NACHT, LRR and PYD domains-containing protein 3 P2X purinoceptor PYD and CARD domain containing Pannexin Proline-serine-threonine phosphatase interacting protein 1 Thioredoxin-interacting protein Thioredoxin Uncharacterized protein	A0A8I3N9V3 A0A8I3ND03 A0A8I3NKV1 A0A8I3P020 A0A8I3PDQ2 A0A8I3PGK7 A0A8I3PV78 A0A8I3RQW6 A0A8I3RXE3 A0A8I3RYZ8	HSP90AB1 MEFV NLRP3 P2RX7 PANX PANX1 PSTPIP1 PYCARD SUGT1 TXN TXNIP	Canis familiaris (dog)
MET interacts with TNS proteins	Hepatocyte growth factor receptor Hepatocyte growth factor Integrin beta Tensin 3 Tensin 4	A0A8I3MMP8 A0A8I3N5C8 A0A8I3NGY1 A0A8I3NIW4 Q867B7	HGF ITGB1 MET TNS3 TNS4	Canis familiaris (dog)
MET activates STAT3	Hepatocyte growth factor receptor Hepatocyte growth factor Signal transducer and activator of transcription	A0A8I3NGY1 A0A8I3RV66 Q867B7	HGF MET STAT3	Canis familiaris (dog)
Drug-mediated inhibition of MET activation	Hepatocyte growth factor receptor Hepatocyte growth factor	A0A8I3NGY1 Q867B7	HGF MET	Canis familiaris (dog)
Histamine receptors	Histamine H1 receptor Histamine H2 receptor Histamine receptor H3 Histamine receptor H4	A0A8I3MSX9 A0A8I3NPW0 A0A8I3P226 P17124	HRH1 HRH2 HRH3 HRH4	Canis familiaris (dog)
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Hypocretin neuropeptide precursor Orexin receptor type 2 Orexin/Hypocretin receptor type 1 Pyroglutamylated RFamide peptide receptor Pyroglutamylated RFamide peptide	A0A8I3PCA6 A0A8I3PCK7 A0A8I3RSX8 Q9GLF6 Q9TUP7	HCRT HCRTR1 HCRTR2 OX PPOX QRFP QRFPR	Canis familiaris (dog)
Phosphorylation of CD3 and TCR zeta chains	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase protein-tyrosine-phosphatase protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3NYA3 A0A8I3P4A1 A0A8I3P4Z0 A0A8I3P564 A0A8I3P598 A0A8I3PAB8 A0A8I3PC26 A0A8I3PV90 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 CSK DLA-DQA1 DLA-DRA HLA-DQB2 LCK PAG1 PTPN22 PTPRC PTPRJ TRAV29DV5	Canis familiaris (dog)
Translocation of ZAP-70 to Immunological synapse	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3P4A1 A0A8I3P564 A0A8I3P8U2 A0A8I3PAB8 A0A8I3PC26 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 DLA-DQA1 DLA-DRA HLA-DQB2 LCK PTPN22 TRAV29DV5 ZAP70	Canis familiaris (dog)
Elevation of cytosolic Ca2+ levels	Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor P2X purinoceptor Transient receptor ion channel domain-containing protein Transient receptor potential cation channel subfamily C member 3 Transient receptor potential cation channel subfamily C member 7	A0A8I3MK71 A0A8I3NKB2 A0A8I3NUS5 A0A8I3NX68 A0A8I3P313 A0A8I3PPB8 A0A8I3PV78 A0A8I3PW88 A0A8I3Q0A9 A0A8I3Q2P2 A0A8I3QCF1 A0A8I3S1Y6 A0A8I3S3K0	ITPR1 ITPR2 ITPR3 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 TRPC3 TRPC6 TRPC7	Canis familiaris (dog)
IRS-related events triggered by IGF1R	Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor substrate 4 Insulin-like growth factor I Insulin-like growth factor II Tyrosine-protein kinase receptor	A0A8I3NI15 A0A8I3NVW9 A0A8I3PAR4 A0A8I3RQ77 A0A8I3S0I1 P33712	IGF1 IGF1R IGF2 IGFIA IRS1 IRS2 IRS4	Canis familiaris (dog)
IRS-mediated signalling	Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A5F4C2B1 A0A8I3N971 A0A8I3NVW9 A0A8I3PWT3 A0A8I3S0I1 A0A8I3S3N2	IRS1 IRS2 PIK3CA PIK3CB PIK3R1 PIK3R2	Canis familiaris (dog)
Signaling by Insulin receptor	Insulin Tyrosine-protein kinase receptor	A0A8I3PWD4 P01321	INS INSR	Canis familiaris (dog)
Relaxin receptors	Insulin-like 3 Relaxin 2 Relaxin family peptide receptor 1 Relaxin family peptide receptor 3 Relaxin receptor 2 Relaxin-3	A0A8I3NLX3 A0A8I3PPP9 A0A8I3RPW6 A0A8I3RZ39 Q5XM32 Q6X7V3	INSL3 LGR8 RLF RLN2 RLN3 RXFP1 RXFP2 RXFP3	Canis familiaris (dog)
Interleukin-2 signaling	Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 SHC-transforming protein 1 Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase non-specific protein-tyrosine kinase	A0A8I3MVN6 A0A8I3N974 A0A8I3NAC6 A0A8I3NUU1 A0A8I3P3G0 A0A8I3RRY0 A0A8I3RS40 A0A8I3RVE7 A0A8I3RYS0 A0A8I3S4Z2 Q29416	IL2 IL2RA IL2RB JAK1 JAK3 LCK PTK2B SHC1 STAT5A STAT5B SYK	Canis familiaris (dog)
Phase 4 - resting membrane potential	Inward rectifier potassium channel 2 Inward rectifier potassium channel Potassium channel domain-containing protein Potassium channel subfamily K member 9 Potassium channel subfamily K member Potassium inwardly rectifying channel subfamily J member 14 Potassium two pore domain channel subfamily K member 10 Potassium two pore domain channel subfamily K member 12 Potassium two pore domain channel subfamily K member 13 Potassium two pore domain channel subfamily K member 15 Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 17 Potassium two pore domain channel subfamily K member 18 Potassium two pore domain channel subfamily K member 4 Potassium two pore domain channel subfamily K member 5 Potassium two pore domain channel subfamily K member 6 Potassium two pore domain channel subfamily K member 7	A0A8I3MR75 A0A8I3MTD8 A0A8I3MV05 A0A8I3N317 A0A8I3NAZ8 A0A8I3NNF9 A0A8I3NSP8 A0A8I3NUT1 A0A8I3NUY1 A0A8I3P863 A0A8I3Q3Z0 A0A8I3Q644 A0A8I3RRG3 A0A8I3S0J2 A0A8I3S6X0 F6KIF6 Q9MYY9	IRK1 KCNJ12 KCNJ14 KCNJ2 KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK18 KCNK3 KCNK4 KCNK5 KCNK6 KCNK7 KCNK9	Canis familiaris (dog)
Opsins	Long-wave-sensitive opsin 1 Melanopsin Opsin 3 Opsin 5 Retinal G protein coupled receptor Retinal pigment epithelium-derived rhodopsin homolog Rhodopsin Short-wave-sensitive opsin 1	A0A8I3N0P5 A0A8I3NDC4 A0A8I3PJU6 A0A8I3Q2S6 A0A8I3QE57 A0A8I3RTH5 E2R3W5 O18914	OPN1LW OPN1SW OPN3 OPN4 OPN5 RCP RGR RHO RRH	Canis familiaris (dog)
Hydrolysis of LPC	Lysosomal phospholipase A and acyltransferase Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase B-like	A0A8I3MZB9 A0A8I3P3G6 A0A8I3P464 A0A8I3PKA9 A0A8I3QXI0 A0A8I3RZX3 Q6XPZ3	LYPLA3 PLA2G15 PLA2G4A PLA2G4B PLA2G4D PLA2G4E PLA2G4F PLBD1	Canis familiaris (dog)
Ficolins bind to repetitive carbohydrate structures on the target cell surface	MBL associated serine protease 1 MBL associated serine protease 2 Uncharacterized protein	A0A8I3MRI0 A0A8I3NLF4 A0A8I3PG15	FCN2 MASP1 MASP2	Canis familiaris (dog)	G49108TO G57321FI

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